New Study Explains How Fish Oil Can Help Reverse Insulin Resistance And Reduce ‘Bad Cholesterol’
March 12, 2025 by Mariam Qayum
Insulin resistance occurs when the body’s cells become less responsive to insulin, leading to higher blood sugar levels and increasing the risk of type 2 diabetes. It is often associated with high levels of “bad” LDL cholesterol, which can contribute to heart disease. However, a recent study claims that fish oil, rich in omega-3 fatty acids, has been shown to help reverse insulin resistance and reduce LDL cholesterol levels.
Insulin resistance is considered the underlying cause of various conditions, including PCOS, diabetes, fatty liver disease, metabolic syndrome, and certain types of cancer. According to a recent study published in Nutrients, researchers found that administering 2 grams of fish oil per kilogram of body weight, three times a week for eight weeks, reduced insulin resistance in non-obese rats. Read on to learn more.
Fish Oil's Link To Insulin Resistance And "Bad" Cholesterol
Insulin resistance happens when the body's cells no longer respond effectively to insulin, causing blood sugar levels to rise. In the experiment, these rats showed improved blood sugar levels, reduced inflammatory markers, and better lipid profiles, including lower total cholesterol, LDL (“bad cholesterol”), and triglycerides.
“Our experiments involved Goto-Kakizaki [GK] rats, an animal model for non-obese type 2 diabetes. We found that insulin resistance can be reduced in these animals by modulating the inflammatory response so as to change the profile of defense cells [lymphocytes] from a pro-inflammatory state to an anti-inflammatory state. This process parallels the response of obese individuals with insulin resistance to omega-3 fatty acid supplementation,” said Rui Curi, director of Butantan Institute’s Education Center, professor of Interdisciplinary Graduate Studies in Health Sciences at Cruzeiro do Sul University (UNICSUL), and coordinator of the study.
Renata Gorjão, last author of the article and co-director of UNICSUL’s Program of Graduate Studies in Health Sciences, added, “The main aim of the study, therefore, was to find out whether supplementation with fish oil [rich in omega-3] could reverse specific alterations in lymphocytes that had been observed in previous research. Our findings increased our knowledge of the link between inflammation and insulin resistance in non-obese animals, confirming that this is a key factor in diabetes even in the absence of obesity."
The bottom line
These findings highlight the potential of fish oil as a natural aid in combating insulin resistance and lowering LDL cholesterol, both of which are crucial for maintaining overall metabolic and heart health.
While more research is needed to determine the full extent of its benefits in humans, this study reinforces the importance of omega-3 fatty acids in supporting a healthy inflammatory response and improving insulin sensitivity.
Incorporating fish oil into a balanced diet—whether through supplements or fatty fish like salmon and mackerel—could be a simple yet effective way to promote long-term health.