What is NMN?
Nicotinamide Mononucleotide (NMN) is a molecule found in all of the cells of the body, serving as a key building block for Nicotinamide Adenine Dinucleotide (NAD), a vital coenzyme responsible for energy production, DNA repair, and overall cellular function. As we age, our NAD levels decline, leading to decreased cell function and a higher risk of age-related diseases. Research and studies prove that taking NMN supplements can effectively boost NAD levels, promoting better health and potentially slowing the aging process. Unlike direct NAD supplements, which cannot enter cells due to their size, NMN can easily penetrate and convert into NAD once inside, delivering the essential benefits that support improved cellular health, energy metabolism, DNA repair, and longevity. By restoring NAD levels through NMN, we can help maintain cellular efficiency which in turn improves our well-being, and counteract the effects of aging.
Why is NMN Considered the Best NAD Precursor?
Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) have gained attention as popular supplements to increase NAD levels. While NAD cannot be taken as an effective supplement, smaller molecules like NMN and NR can pass through the digestive system intact. NMN is often preferred due to its ability to be directly absorbed into cells, leading to quicker NAD boosts compared to NR, which must first be converted into NMN within the body. This direct conversion makes NMN potentially more efficient for enhancing functions like mitochondrial activity and DNA repair.The direct pathway from NMN to NAD suggests NMN might be more effective at boosting cellular functions tied to higher NAD levels, while NR’s effectiveness is less clear due to its additional conversion step and lacking sufficient supporting research.
While alternatives like NAD injections or IV therapies exist, they can be quite costly, invasive and require clinical oversight, making them less practical for everyday use. As previously mentioned, oral NAD pills also remain ineffective because of NAD’s inability to cross the cell membrane. In contrast, NMN offers a more convenient and effective solution. As a small, absorbable molecule, it can be taken orally and efficiently processed into NAD within cells, providing a natural way to enhance cellular health and longevity without the need for medical procedures or absorption issues.
Amidst the latest breakthroughs in the biomedical world, Nicotinamide Mononucleotide (NMN) has gained recognition as a powerful supplement with exciting potential for enhancing female fertility, hormonal balance, menopausal health, and skin and hair vitality. Its potential to improve overall cellular health makes it a standout in the field of anti-aging and women’s wellness. Here are the top benefits of NMN that will redefine the way we approach women’s health:
Fertility & Hormonal Balance and NMN
Parenthood is one of the most profound experiences of life and for many, becoming a parent marks the beginning of a new chapter filled with love, growth, and connection. However, the journey to parenthood can be emotionally taxing, especially when faced with fertility issues. Understanding and addressing fertility issues can help couples regain control and find peace during a deeply personal and often stressful process.
Exciting new research shows how NAD, boosted by NMN supplements, could hold the key to improving fertility and slowing down ovarian aging—offering new possibilities for women looking to improve their reproductive health. Several researches indicate that NMN may enhance female fertility by improving egg quality, boosting mitochondrial function, lowering oxidative stress, and supporting DNA repair and hormonal balance. These discoveries not only expand our understanding of reproductive health but also create new opportunities for fertility treatments, particularly for women of advanced age.
Improved Oocyte Quality
Research has revealed that NMN supplementation may be a game-changer in enhancing fertility, particularly in aging females. Studies in older female animals have shown that NMN significantly boosts the quality of egg cells, increasing the number of mature oocytes ready for fertilization and leading to higher quality embryos. This boost in fertility is linked to sirtuins, special enzymes that rely on NAD to combat oxidative stress and support cellular health, helping to preserve the quality of oocytes as they age.
In one groundbreaking study, researchers administered NMN in the drinking water of 13-month-old mice for four weeks. The results were striking: egg quality, ovulation rates, and live birth outcomes all improved, especially at lower doses of NMN. These treated mice saw quicker times to their first live birth and had a greater number of successful pregnancies, highlighting the real potential of NMN in restoring fertility during reproductive aging.
Further research confirmed these findings, showing that NMN improves chromosomal alignment in older oocytes, leading to better egg quality and increased fertility. This growing body of evidence suggests that NMN could enhance ovarian function, replenish ovarian reserves and potentially extend a woman’s reproductive window, offering new hope for fertility treatments as women age.
Enhanced Mitochondrial Function
We all remember learning in school that mitochondria are the cell’s powerhouse, fueling vital processes that keep our bodies running. When the energy engines of our cells function at their best, everything from cellular health to fertility thrives.
But did you know that boosting NAD can supercharge these tiny engines? NMN not only does wonders for women’s energy levels but research also shows that higher NAD levels reduce oxidative stress, which is crucial for better egg quality and an increase in mature eggs. Lower oxidative stress means healthier eggs, improved fertility outcomes, and protection against DNA damage. NMN supplementation helps shield eggs from oxidative harm, improving their quality and viability, leading to better embryo development. This makes NMN a promising solution for tackling fertility challenges related to aging eggs, as replenishing NAD has been proven to restore female fertility during reproductive aging. On top of that, increased NAD can also boost cellular energy production, helping to ease fatigue and improve mental clarity—two common concerns during menopause.
DNA Repair
NMN plays a vital role in supporting the body’s DNA repair mechanisms, helping to ensure the genetic material within oocytes remains intact and healthy. This is especially important because DNA damage in oocytes can significantly affect fertility, often leading to difficulties in conception or even developmental issues in embryos. By maintaining the integrity of this genetic material, NMN not only improves the quality of the oocytes but also enhances the chances of a successful and healthy pregnancy. In essence, safeguarding the DNA in these cells is crucial for both fertility and the proper development of the next generation, making NMN a significant player in reproductive health. With its ability to help protect against potential DNA damage, NMN offers a promising path for improving fertility outcomes, particularly for women facing reproductive challenges in later years.
Hormonal Balance and Follicular Development
When it comes to fertility, hormonal balance is everything. It is vital for maintaining reproductive health and increasing the chances of successful conception. NMN helps with hormonal balance in women by playing an integral role in regulating the levels of fertility hormones such as estrogen, maintaining a healthy menstrual cycle, promoting regular ovulation, and supporting the development of ovarian follicles. While much of this research has been on mice so far, the conclusive findings are encouraging, and there’s reason to believe these benefits will translate to humans.
Menopausal Health
NMN Restores Vitality During Menopause
As women approach menopause, they often face a variety of uncomfortable changes from hot flashes and night sweats to mood swings and brain fog—but what if there was a way to help ease these transitions? One crucial factor that declines during menopause is NAD, a molecule vital for maintaining our cellular health. When NAD levels drop, it can lead to slower cellular repair, hormonal imbalances, fatigue, cognitive decline, and reduced energy. Findings suggest that targeting NAD levels could not only reverse these effects but also enhance overall well-being during aging, as menopause is closely linked to women’s healthspan and lifespan. Enhancing NAD may offer a powerful solution for reducing menopause-related symptoms and supporting overall well-being as women age.
NMN Combats Inflammation and Improves Cellular Repair
It’s a well known fact that the estrogen levels undergo a significant decline as menopause enters. And estrogen isn’t just a reproductive hormone—it also plays an important role in regulating various functions throughout the body, including inflammation and cellular repair. When estrogen decreases, the body can become more prone to inflammation and inflammation is essentially the body’s response to damage or stress. The problem lies when it becomes chronic, as it can contribute to aging and various health issues like joint pain, skin changes and even cardiovascular problems. Estrogen also supports the body’s ability to repair and maintain itself at the cellular level, which means that without enough estrogen, the body’s ability to repair damaged cells (including skin, muscle, and other tissues) slows down.
By increasing NAD levels—through supplements like Wonderfeel Youngr™ NMN —the body will regain some of its capacity to repair itself. NAD assists in repairing damaged DNA, which is crucial because DNA damage accumulates with age, and helps manage inflammation by regulating immune responses. When inflammation is kept in check, the body will experience less wear and tear, leading to healthier aging during menopause.
NMN Improves Bone Health
Menopause often leads to a loss of bone density, raising the risk of osteoporosis. Although more research is needed to fully understand NAD’s direct role in bone health, improving cellular health and lowering oxidative stress may help support stronger bones and lower the chances of fractures.
NMN Increases Insulin Sensitivity
A 2021 study published in Science Magazine discovered that NMN enhances muscle insulin sensitivity, boosts insulin signaling, and promotes muscle remodeling in women who are overweight or have prediabetes. This research focused on postmenopausal women and examined how NMN supplementation affects their metabolic health. In this trial, 25 women were randomly assigned to receive either NMN or a placebo daily for 10 weeks—13 took NMN, while 12 were given a placebo.
Key results showed that:
– NMN improved muscle insulin sensitivity by 25% compared to the placebo group, an effect similar to what is seen with a 10% weight loss.
– There was also an increase in the activation of AKT and mTOR, two important proteins involved in insulin signaling.
These results suggest that NMN could be a promising option for increasing insulin sensitivity and supporting overall metabolic health, especially for women managing prediabetes.
Skin & Hair Health
NMN Reverses the Signs of Skin Aging
Discover the secret to smoother, more youthful skin with a little help from NMN: A Japanese study published in Glycative Stress Research found that NMN supplementation in older women significantly improves skin health by reducing glycation. Glycation occurs when sugar molecules bind to proteins or fats in the skin, leading to the formation of advanced glycation end products (AGEs). And these AGEs contribute to skin aging by weakening collagen and elastin of our skin. This study also observed improvements in the metabolic and hormonal balance, supporting NMN’s even bigger role in skin rejuvenation. These findings suggest that NMN could help reverse signs of aging and enhance skin’s quality, particularly in postmenopausal women.
NMN Boosts Skin Hydration, Elasticity, and Firmness
NMN also helps improve skin by boosting the production of hyaluronic acid and ceramides, two essential components for keeping the skin moisturized and its protective barrier strong. Recent research including a nanoparticle delivery method revealed that NMN can effectively penetrate skin cells, encouraging higher levels of hyaluronic acid. This results in better moisture retention, enhanced elasticity, and a firmer appearance for the skin. These findings suggest that NMN could play a vital role in skincare routines aimed at deep hydration and reducing visible signs of aging.
NMN Shields Skin from UV Damage
As an integral molecule of all our cells, NAD plays a key role in repairing damaged DNA and supporting the overall cellular health, making it essential for the skin’s defense against UV exposure and the aging process. NMN helps boost NAD levels, which in turn strengthens the skin’s ability to repair DNA damage caused by UV rays through the nucleotide excision repair (NER) process. This repair system targets DNA issues like CPDs and 6-4PPs, significantly lowering the risk of photoaging and even skin cancers. With NMN, you’re not just protecting your skin from the sun—you’re giving it the tools to thrive and age gracefully.
NMN Minimizes Age Spots
Fed up with stubborn age spots and uneven skin tone? Recent research points to NMN as a promising solution for reducing age spots and hyperpigmentation that occur with aging. NMN works by lowering melanin production in older skin cells, through the downregulation of receptors involved in melanogenesis. Animal studies, published in the Journal of Dermatological Science, back NMN’s effectiveness in this area. This reduction in melanin production is consistent with user feedback, reporting fewer age spots, making NMN a potential option for addressing hyperpigmentation associated with aging.
Wonderfeel Youngr™ NMN defends skin health with its advanced blend of NMN, ergothioneine, hydroxytyrosol, resveratrol, and Vitamin D3. This unique formula harnesses the power of antioxidants—ergothioneine from mushrooms, hydroxytyrosol from olives, and resveratrol from grapes—to combat inflammation and oxidative stress in skin cells. By neutralizing free radicals, these antioxidants safeguard vital cellular components, including DNA, proteins, and lipids, from oxidative damage. This protective mechanism supports overall skin health and helps to prevent premature aging.
Vitamin D3 is essential for regulating the immune response, especially in controlling inflammation. It influences lymphocyte function and cytokine production, both processes critical for a well-balanced immune system. By managing these processes, Vitamin D3 helps keep inflammatory responses in check and supports overall immune balance. Insufficient Vitamin D3 levels are linked to various skin disorders, systemic infections, and even some cancers. Maintaining adequate Vitamin D3 through supplements such as Wonderfeel Youngr™ NMN and safe sun exposure is crucial for overall skin health.
NMN Revitalizes Hair Growth
Imagine a treatment that not only combats hair loss but also promotes the growth of fuller, thicker hair: NMN can do both! A 2023 study examined NMN’s effects on hair growth using an animal model to understand its impact and underlying mechanisms. The research found that NMN effectively counteracts hair follicle shrinkage, thinning, and reduced hair density caused by dihydrotestosterone, showing results similar to those of minoxidil, a well-known medication used to treat hair loss. These findings suggest that NMN could be a powerful option for addressing hair loss as well as fostering the growth of healthier, vibrant hair.
Wonderfeel Youngr™ NMN combines NMN, ergothioneine, resveratrol, and Vitamin D3 to offer incredible benefits for hair health. This dynamic formula not only promotes hair growth but also tackles oxidative stress and supports follicle health.
Scientific research reveals that ergothioneine plays a crucial role in shielding hair follicles from oxidative stress—a leading cause of hair loss and thinning. By minimizing oxidative damage and inflammation, ergothioneine fosters healthier hair growth and helps alleviate stress-related impacts on follicles. Resveratrol is known for its positive impact on hair growth by enhancing the Wnt/β-catenin signaling pathway, which is key to hair follicle development and growth. This pathway helps hair follicles stay in the growth phase, known as the anagen phase, where hair is actively produced. At the same time, resveratrol helps delay the transition to the catagen phase, which is a brief period where hair follicles prepare to shed. Research shows that resveratrol increases the activity of β-catenin in hair follicle cells, which promotes longer and healthier hair growth by extending the anagen phase and postponing the shedding phase.
Wonderfeel has emerged as a pioneering force in the wellness industry, redefining the way we think about longevity and cellular health. Co-founded by Baran Dilaver and Patricia Ryan, alongside their Chief Medical Officer, Harvard MD Dr. Andrew Salzman, Wonderfeel is making advanced health solutions accessible to all. The company’s flagship product, Wonderfeel Youngr™ NMN, is a testament to their commitment to high-quality, science-backed formulation. Patricia Ryan, the driving force behind Wonderfeel’s branding and outreach, has played a pivotal role in shaping the company’s vision of empowering consumers to take control of their health. With a focus on women’s health, particularly in addressing the unique challenges of aging, Wonderfeel is positioning itself as a leader in anti-aging innovation, particularly as the conversation around NMN and fertility gains momentum.
Patricia Ryan’s leadership and dedication to women’s issues are especially evident as Wonderfeel ventures into research surrounding NMN’s potential benefits for ovarian health, menopause, and fertility. Speaking on the topic, Ryan emphasizes the importance of prioritizing women’s health in an industry that has often overlooked these critical areas. “Although women account for more than 50% of the U.S. population, every medication, treatment, and medical school textbook is based on men and their bodies. But a health revolution is underway that women can get excited about. With a recent executive order, the government has committed $12 billion to equally study women’s health issues. This is a pivotal change, considering it took until 1993 for federally-funded research to include women. And to drive this point home, a 1970s study investigating estrogen’s impact on heart attacks famously excluded women, enrolling 8,341 men instead,” she says. Backed by promising preclinical research, Wonderfeel is currently exploring the specific impact of NMN on perimenopause and post-menopausal health, aiming to support women through every stage of life. This dedication to comprehensive, evidence-based solutions is what sets Wonderfeel apart as a brand that truly champions both longevity and women’s well-being.
Women are at the forefront of the health revolution, and it’s time their unique needs are addressed with the same rigor as any other sector of wellness.
Frequently Asked Questions
At what age should women start taking NMN?
Many experts suggest that women should consider starting NMN supplementation around the age of 30. This age is when the body’s natural production of NAD, a vital coenzyme for cellular function, begins to decline—typically starting in our late 20s or early 30s and accelerating with age. While younger individuals usually produce sufficient NAD on their own, women over 30 may benefit from NMN to help maintain optimal cellular health and vitality. By boosting NAD levels, NMN supports overall wellness and helps counteract the effects of aging on cellular function, paving the way for a vibrant and healthy life as you continue to age. Starting early can be a proactive step toward long-term reproductive health and well-being.
What is the recommended NMN dosage for women?
When it comes to maximizing the benefits of NMN, finding the right dosage is essential. Experts like Dr. David Sinclair and Dr. Andrew Salzman recommend a daily intake of around 900mg to 1000mg for women to effectively harness NMN’s potential for fertility, menopausal and ovarian health. Research from 2021 indicates that a safe and effective starting range is between 600mg and 1200mg, while doses below 400mg may not yield noticeable benefits. Interestingly, studies have shown that daily intakes of up to 2000mg are generally well-tolerated, allowing for adjustments based on individual needs and health goals. It’s crucial to pay attention to how your body responds, but the general consensus among experts suggests aiming for that 900mg to 1000mg range to achieve optimal results with NMN. This tailored approach can help you truly unlock the power of this supplement!
What are the initial benefits of NMN for women?
Many women who begin supplementing with NMN often notice an immediate boost in energy and a more robust feeling. This quick improvement is due to NMN rapidly converting into NAD, which fuels cellular energy production. As a result, women frequently report reduced fatigue and increased vitality, helping them feel more active and energized in their daily lives. While these immediate benefits are certainly encouraging, it’s essential to understand that the most substantial improvements from NMN emerge with consistent, long-term use. Over time, NMN can lead to deeper enhancements in overall health, particularly in crucial areas like reproductive health, hormonal balance, and fertility. Embracing NMN as part of your wellness routine can truly transform how you feel from the inside out!
Can NMN be used alongside other supplements for women’s health?
Absolutely! NMN can be safely used alongside other popular supplements for women’s health, like Magnesium, Calcium, Vitamin D, and Omega-3 fatty acids. Many women find that pairing NMN with these nutrients not only enhances their individual benefits but also supports overall well-being. The good news is that NMN absorbs well, whether taken with or without food, so it easily fits into your daily routine, no matter how busy life gets. You can experiment with taking it alongside your regular supplements to see what works best for you. Since everyone’s body responds differently, it’s all about finding the combination that gives you the most energy and vitality. This flexible approach can help you feel more in control of your health and wellness journey.
Are there any side effects of taking NMN for women?
If you’re worried about potential side effects from taking NMN supplements, the existing research should offer some reassurance. A study from 2023 involving participants aged 55 to 80 examined the safety of NMN supplementation, with individuals receiving doses as high as 2000 mg of a specific NMN variant, MIB-626, daily for two weeks.
The findings affirmed the safety of NMN and NMN was well-tolerated even at higher doses, and no significant side effects were reported. Hence NMN can be safely integrated into women’s wellness routines without concerns about its adverse effects. With this growing body of evidence, women can feel confident incorporating NMN into their health regimen, knowing it supports overall well-being without compromising safety.
How does NMN support anti-aging in women?
NMN supports anti-aging in women through multiple mechanisms, all of which target the root causes of cellular decline and help to maintain youthful vitality:
Improved Cellular Function and DNA Repair: One of NMN’s most powerful anti-aging benefits is its ability to boost NAD levels, which are essential for cellular energy production and repair. As women age, NAD levels naturally decline, leading to slower cellular repair and more accumulated DNA damage. NMN helps replenish NAD, supporting the body’s ability to fix damaged DNA, especially in oocytes (egg cells). By protecting and repairing genetic material, NMN helps maintain fertility and improve overall cellular health, which is key in slowing down the aging process.
Better Mitochondrial Function: Mitochondria become less efficient with age. However NMN boosts mitochondrial function, increasing cellular energy and reducing oxidative stress. This is particularly beneficial for women as they age, as it leads to improved egg quality, reduced fatigue, and better mental clarity. Keeping mitochondria healthy is a critical factor in slowing down cellular aging, making NMN a valuable supplement for enhancing both reproductive health and overall energy levels.
Hormonal Balance and Menopausal Health: NMN also plays a role in balancing hormones, which is crucial for reproductive health and combating the symptoms of menopause. By helping regulate estrogen and other hormones, NMN can promote regular ovulation and support ovarian follicle development. For women entering menopause, NMN can alleviate common symptoms like fatigue, brain fog, and mood swings by boosting NAD levels, supporting cellular repair, and reducing inflammation. This helps ease the transition into menopause and promotes healthier aging.
Wonderfeel Youngr™ NMN stands out at the forefront of NMN supplements on the market, and for good reason. Developed by renowned Harvard MD and a prominent drug inventor, Professor Andrew Salzman, this patented formula draws on decades of NAD research and over 50 breakthrough patents. Engineered to combat the effects of biological aging, boost cellular energy, enhance cognitive performance, and support overall wellness, Wonderfeel Youngr™ NMN goes above and beyond standard supplements. Its powerful 900 mg dose of premium NMN is complemented by a robust blend of antioxidants, working synergistically to elevate NAD levels. This makes it an ideal choice for those looking to improve fertility, balance hormones, and optimize their health.
The editors at SheFinds wrote this post on behalf of Wonderfeel and received compensation as part of our agreement.
